Description
Anti-CD34 Antibody, Non-Fucosylated (BioBet-661ZP) is a humanized monoclonal IgG1 antibody against CD34. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Hematologic Malignancies; Solid Tumors
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced CD34 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CD34
Full Name
CD34 molecule
Background
The protein encoded by this gene may play a role in the attachment of stem cells to the bone marrow extracellular matrix or to stromal cells. This single-pass membrane protein is highly glycosylated and phosphorylated by protein kinase C. Two transcript variants encoding different isoforms have been found for this gene.
Alternative Names
CD34; CD34 molecule; hematopoietic progenitor cell antigen CD34; CD34 antigen
Gene ID
947
UniProt ID
Q5ZPR3
Cellular Localization
Membrane
Involvement in Disease
Diseases associated with CD34 include Dermatofibrosarcoma Protuberans and Spindle Cell Lipoma.
Related Pathways
Its related pathways are C-MYB transcription factor network and Hematopoietic cell lineage.
Function
By mediating stem cells to attach to the extra-marrow matrix or directly attach to stromal cells, adhesion molecules that may play a role in the early hematopoietic process. It can be used as a scaffold for cell line-specific polysaccharides to bind stem cells to lectins expressed by stromal cells or other bone marrow components. Provide carbohydrate ligands for selection.
Field of research
Cancer antibody; Cell Biology and Cellular Response antibody; Controls and Markers antibody; Developmental Biology antibody; Immune System antibody; Neuroscience antibody; Pro-B Cell Marker antibody; Endothelial Cell Marker antibody; Angiogenesis Study antibody
Post-translational modifications
Highly glycosylated. Phosphorylated on serine residues by PKC.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1
Antibody Clone
BioBet-661ZP
Description
The anti-CD34 antibody that recognize the CD34 membrane-protein in the cell membrane, can be used in the clinical treatment of hematologic malignancies and solid tumors, hematopoietic stem / progenitor cells transplantation.
Antibody Indication
Hematologic Malignancies; Solid Tumors
Hematologic Malignancies; Solid Tumors
