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Non-Fucosylated Anti-Human CD200 receptor (DXl 82) Therapeutic Antibody (CAT#: BioBet-648ZP) Datasheet

Target
CD200 receptor
Isotype
IgG1
Description
ADCC-Enhanced anti-CD200 receptor (DXl 82) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.
Indication
Autoimmune Diseases; Inflammatory Diseases
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced CD200 receptor antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CD200R1
Full Name
CD200 receptor 1
Background
This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants.
Alternative Names
CD200R1; CD200 receptor 1; OX2R; MOX2R; CD200R; HCRTR2; cell surface glycoprotein CD200 receptor 1; MOX2 receptor; CD200 cell surface glycoprotein receptor; cell surface glycoprotein OX2 receptor 1; cell surface glycoprotein receptor CD200
Gene ID
131450
Cellular Localization
Plasma membrane, Extracellular region or secreted
Involvement in Disease
Diseases associated with CD200R1 include Human Herpesvirus 8 and Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1.
Related Pathways
Its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation.
Function
CD200/OX2 cell surface glycoprotein inhibitory receptor. By inhibiting the expression of pro-inflammatory molecules, including tnf--, interferon, and inducible nitric oxide synthase (iNOS) in response to specific stimuli to limit inflammation. It also binds to CD200, the homologue of HHV-8 K14 virus, and has the same affinity and kinetics as the host CD200.
Post-translational modifications
The mature form of isoform 2 and/or isoform 4 starts at sequence position 27 of the corresponding isoform.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1
Antibody Clone
DXl 82
Host
Humanized
Species Reactivity
Human
Description
The antibody binding compounds specific for the human inhibitory CD200R can be used to modulate its activity in inflammatory and autoimmune disorders.
Indication
Autoimmune Diseases; Inflammatory Diseases

Autoimmune Diseases; Inflammatory Diseases

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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