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Non-Fucosylated Anti-Human CD1d (401. 11) Therapeutic Antibody (CAT#: BioBet-646ZP) Datasheet

Target
CD1d
Isotype
IgG
Description
ADCC-Enhanced anti-CD1d (401.11 ) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.
Indication
Liver Disease
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced CD1d antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CD1D
Full Name
CD1d molecule
Background
This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail.
Alternative Names
CD1D; CD1d molecule; R3; CD1A; antigen-presenting glycoprotein CD1d; R3G1; thymocyte antigen CD1D; CD1D antigen, d polypeptide; T-cell surface glycoprotein CD1d; differentiation antigen CD1-alpha-3; HMC class I antigen-like glycoprotein CD1D
Gene ID
912
Cellular Localization
Plasma membrane, Endosome, Lysosome, Endoplasmic reticulum
Involvement in Disease
Diseases associated with CD1D include Mycobacterium Malmoense and Glottis Neoplasm.
Related Pathways
Its related pathways are Hematopoietic cell lineage and Innate Immune System.
Function
Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.
Post-translational modifications
1.Glycosylation at Asn38, Asn60, Asn126, and Asn181 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
401. 11
Host
Human
Species Reactivity
Human
Description
The antibody can bind CD1d and inhibit CD1d- mediated biological functions such as activation of the CDld-restricted T cell, natural killer T (NKT) cells.
Indication
Liver Disease

Liver Disease

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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