Non-Fucosylated Anti-Human CD179b (#8) Therapeutic Antibody (CAT#: BioBet-1038ZP) Datasheet

IGLL1

immunoglobulin lambda-like polypeptide 1

The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene.

IGLL1; immunoglobulin lambda-like polypeptide 1; IGO; 14.1; AGM2; IGL1; IGL5; IGLL; IGVPB; CD179b; VPREB2; IGLJ14.1; lambda5; ig lambda-5; CD179b antigen; CD179 antigen-like family member B; Pre-B lymphocyte-specific protein-2; immunoglobulin-related 14.1 protein; immunoglobulin-related protein 14.1; immunoglobulin omega polypeptide chain

Extracellular region or secreted, Endoplasmic reticulum

Diseases associated with IGLL1 include Agammaglobulinemia 2, Autosomal Recessive and Agammaglobulinemia, Non-Bruton Type.

Its related pathways are Cell surface interactions at the vascular wall and Response to elevated platelet cytosolic Ca2+.

Critical for B-cell development.

1.Modification sites at neXtProt 2.Modification sites at PhosphoSitePlus

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

#8

Humanized

Human

This is an antibody having immunoreactivity to a polypeptide comprising not less than 7 continuous amino acids in the CD179b protein, which was identified as a cancer antigen protein specifically expressed on the surfaces of cancer cells, can be used as a pharmaceutical composition for therapy and/or prophylaxis of cancer.

Cancer

Cancer