Non-Fucosylated Anti-Human CCR2 (MLN1202) Therapeutic Antibody (CAT#: BioBet-633ZP) Datasheet

CCR2

chemokine (C-C motif) receptor 2

This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene.

CCR2; chemokine (C-C motif) receptor 2; CKR2; CCR-2; CCR2A; CCR2B; CD192; CKR2A; CKR2B; CMKBR2; MCP-1-R; CC-CKR-2; MCP-1 receptor; monocyte chemoattractant protein 1 receptor; monocyte chemotactic protein 1 receptor

Plasma membrane

Diseases associated with CCR2 include Human Immunodeficiency Virus Type 1 and Idiopathic Anterior Uveitis.

Its related pathways are Signaling by GPCR and Defensins.

The key functional receptor for CCL2, but it can also bind to CCL7 and CCL12. It binds to CCL2 on monocytes and macrophages, and induces chemotaxis and migration (possibly) by activating the PI3K cascade, small G protein Rac, and plate platform protrusions. It also acts as a receptor for the defensins DEFB106A/DEFB106B. Regulates the expression of T cell inflammatory factors and T cell differentiation, and promotes T cell differentiation into T-helper 17 cells (Th17) (through similarity) during inflammation. Promote the output of mature thymocytes, enhance the directional movement of thymocytes stimulated by sphingosine-1-phosphate and up-regulate S1P1R expression; regulate FOXO1 activity through the JAK-STAT pathway, resulting in increased S1P1R expression (through similarity). Plays an important role in mediating neuropathic pain caused by peripheral nerve injury (similar). The increase in nmda-mediated synaptic transmission in both dopamine D1 and D2 receptor neurons may be caused by MAPK/erk-dependent phosphorylation of GRIN2B/NMDAR2B (similarity). Mediates the aggregation of macrophages and monocytes to the injury site after brain injury (by similarity).

N-glycosylated. Sulfation increases the affinity for both monomeric and dimeric CCL2 with stronger binding to the monomeric form. Binding of sulfated CCR2 to CCL2 promotes conversion of CCL2 from dimer to monomer.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

MLN1202

Humanized

Human

MLN1202 is a humanized monoclonal antibody with high specificity to CCR2, which interrupts MCP-1 binding to CCR2. MLN1202 is being developed for the treatment of immune mediated diseases.

Atherosclerosis; Multiple Sclerosis

Atherosclerosis; Multiple Sclerosis