Full Name
asialoglycoprotein receptor 1
Background
This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Alternative Names
ASGR1; asialoglycoprotein receptor 1; HL-1; ASGPR; ASGPR1; CLEC4H
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with ASGR1 include Hepatitis and Hepatitis B.
Related Pathways
Its related pathways are Transport to the Golgi and subsequent modification and Aldosterone synthesis and secretion.
Function
Mediates the endocytosis of plasma glycoproteins, and the sialic acid ends on the complex carbohydrate portion are removed. The receptor recognizes terminal galactose and n-acetylgalactosamine units. After the ligand binds to the receptor, the resulting complex is internalized and transported to a sorting organelle, where the receptor and ligand are separated. The receptor then returns to the cell membrane surface.
Post-translational modifications
Phosphorylated on a cytoplasmic Ser residue.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Description
The antibody is capable of specific binding to asialoglycoprotein receptor (ASGPR), used as a medicament, and for use in the treatment or prophylaxis of a liver disease, specifically a viral infection, more specifically hepatitis virus infection, particularly hepatitis B virus (HBV) infection.
