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Non-Fucosylated Anti-Human APRIL (124) Therapeutic Antibody (CAT#: BioBet-1394ZP) Datasheet

Target
APRIL
Isotype
IgG
Description
ADCC-Enhanced anti-APRIL (124) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.
Indication
Cancer
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced APRIL antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
TNFSF13
Full Name
tumor necrosis factor (ligand) superfamily, member 13
Background
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13.
Alternative Names
TNFSF13; tumor necrosis factor (ligand) superfamily, member 13; APRIL; CD256; TALL2; ZTNF2; TALL-2; TRDL-1; UNQ383/PRO71
Gene ID
8741
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with TNFSF13 include Brain Glioblastoma Multiforme and Rheumatoid Arthritis.
Related Pathways
Its related pathways are PEDF Induced Signaling and TRAF Pathway.
Function
Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes.
Field of research
Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Immune System antibody
Post-translational modifications
The precursor is cleaved by furin.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
124
Host
Humanized
Species Reactivity
Human
Description
The antibody raised against APRIL are used to treat various types of cancers, as well as autoimmune disorders.
Indication
Cancer

Cancer

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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