Non-Fucosylated Anti-Human Apelin (Ab A) Therapeutic Antibody (CAT#: BioBet-573ZP) Datasheet

APLN

apelin

This gene encodes a peptide that functions as an endogenous ligand for the G protein coupled receptor APJ. The encoded protein is synthesized as a prepropeptide that is processed into biologically active C-terminal fragments. The peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1.

APLN; apelin; APEL; XNPEP

Extracellular region or secreted

Diseases associated with APLN include Severe Pre-Eclampsia and Heart Disease.

Its related pathways are Signaling by GPCR and Apelin signaling pathway.

1.Endogenous ligand for apelin receptor (APLNR). Drive the internalization of myelin receptors (through similarity). Apelin-36 is more difficult to separate from APLNR (based on similarity) than (pyroglu) apelin-13. Hormones are involved in regulating gastrulation and cardiac morphology (similarity) during the movement of cardiac precursor cells. It has an inhibitory effect on the cytokines produced when the T cell receptor/CD3 is cross-linked; therefore, oral apelin in colostrum and milk may modulate the neonatal immune response (similar). It plays a role in early coronary angiogenesis (similar). Mediates myocardial contractility in an erk1 /2-dependent manner (through similarity). By influencing the release of vasopressin and drinking behavior (through similarity), it may also play a role in the central control of fluid homeostasis. 2.(Microbial infection) Endogenous apelin receptor (APLNR) ligand against HIV-1 infection. Inhibits the entry of HIV-1 in cells co-expressing CD4 and APLNR. Compared with other synthetic apelin derivatives, apelin-36 has stronger inhibitory activity against HIV infection.

Several active peptides may be produced by proteolytic processing of the peptide precursor.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

Ab A

Humanized

Human

The antigen-binding protein may comprise an antibody to apelin and can be used to treat pathological conditions involving angiogenesis. The pathological conditions can comprise cancer or retinopathy and/or retinopathy- related complications.

Retinopathy

Retinopathy