Anti-ADAM17 Antibody, Non-Fucosylated (BioBet-518ZP) (CAT#: BioBet-518ZP) Datasheet

ADAM17

ADAM metallopeptidase domain 17

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway.

ADAM17; ADAM metallopeptidase domain 17; CSVP; TACE; NISBD; ADAM18; CD156B; NISBD

Membrane

Diseases associated with ADAM17 include Inflammatory Skin And Bowel Disease, Neonatal, 1 and Neonatal Inflammatory Skin And Bowel Disease.

Its related pathways are Neuroscience and RET signaling.

The membrane-bound precursor of tnf-is cleaved into a mature soluble form (PubMed:9034191). Responsible for the proteolytic release of soluble JAM3 on the surface of endothelial cells. Responsible for the proteolytic release of other cell surface proteins, including p75 tnf -receptor, interleukin 1 receptor type II, p55 tnf -receptor, transforming growth factor-alpha, l-selectin, growth hormone receptor, MUC1 and Amyloid precursor protein. By mediating the lysis of Notch, it acts as an activator of the Notch pathway to produce a membrane-associated intermediate segment called Notch extracellular truncation (NEXT). Participate in the proteolytic process of ACE2. Hemostasis is exerted by the shedding of GP1BA (platelet glycoprotein Ib-chain) (similar). Mediates the proteolytic cleavage of LAG3, resulting in the release of the secreted form of LAG3 (by similarity). 发送反馈 历史记录

Cancer antibody; Cell Biology and Cellular Response antibody; Developmental Biology antibody; Metabolism antibody; Neuroscience antibody; Signaling Transduction antibody

The precursor is cleaved by a furin endopeptidase. Phosphorylated. Stimulation by growth factor or phorbol 12-myristate 13-acetate induces phosphorylation of Ser-819 but decreases phosphorylation of Ser-791. Phosphorylation at THR-735 by MAPK14 is required for ADAM17-mediated ectodomain shedding.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

BioBet-518ZP

Human

Human

ADCC-Enhanced anti-ADAM17 (D1) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.

Cancer

Cancer