Book a Meeting

Anti-ACVR2A Antibody, Non-Fucosylated (BioBet-512ZP) (CAT#: BioBet-512ZP) Datasheet

Target
ACVR2A
Isotype
IgG
Description
Anti-ACVR2A Antibody, Non-Fucosylated (BioBet-512ZP) is a human monoclonal IgG antibody against ACVR2A. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Bone-related Diseases
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced ACVR2A antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
ACVR2A
Full Name
activin A receptor, type IIA
Background
This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene.
Alternative Names
ACVR2A; activin A receptor, type IIA; ActRIIa
Gene ID
92
UniProt ID
P27037
Cellular Localization
Membrane
Involvement in Disease
Diseases associated with ACVR2A include Fibrodysplasia Ossificans Progressiva and Multiple Synostoses Syndrome.
Related Pathways
Its related pathways are Signaling by NODAL and Signaling by GPCR.
Function
After the ligand binds, a receptor complex composed of two type II and two type I transmembrane serine/threonine kinases is formed. Type II receptors phosphorylate and activate type I receptors, which automatically phosphorylate and then bind and activate SMAD transcriptional regulators. Activin A, Activin B and Inhibin A receptors. Mediates GDF6 to induce adipogenesis (similarity).
Field of research
Developmental Biology antibody; Metabolism antibody; Signaling Transduction antibody
Post-translational modifications
1.Glycosylation at Asn43 and Asn66 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-512ZP
Host
Human
Species Reactivity
Human
Description
Molecules having activin or ActRIIa antagonist activity ("activin antagonists" and "ActRIIa antagonists") can be used to increase bone density, promote bone growth, and/or increase bone strength.
Antibody Indication
Bone-related Diseases

Bone-related Diseases

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

  • *
  • *
  • *
USA

UK

Germany

ISO 9001 Certified - Creative Biolabs Quality Management System.