Non-Fucosylated Anti-Human ACTN4 (15H2) Therapeutic Antibody (CAT#: BioBet-505ZP) Datasheet

ACTN4

actinin, alpha 4

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.

ACTN4; actinin, alpha 4; FSGS; FSGS1; ACTININ-4

Nucleus, Cytoskeleton

Diseases associated with ACTN4 include Focal Segmental Glomerulosclerosis 1 and Genetic Steroid-Resistant Nephrotic Syndrome.

Its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling and Response to elevated platelet cytosolic Ca2+.

F-actin cross-linking protein is believed to anchor actin to a variety of intracellular structures. This is a binding protein (possibly). It may be involved in vesicle transport through participation in the CART consortium. The CART complex is necessary for efficient transferrin receptor recycling, but not necessary for EGFR degradation. It may participate in the tight junction assembly of epithelial cells by interacting with MICALL2. Link MICALL2 to the actin cytoskeleton and recruit it to tight junctions (by similarity). It may also act as a transcriptional co-activator, stimulating transcription mediated by nuclear hormone receptors PPARG and RARA.

Cancer antibody; Metabolism antibody; Signaling Transduction antibody

1.Ubiquitination at Lys181, Lys233, Lys625, Lys632, and Lys859 2.Modification sites at PhosphoSitePlus

Protein Based Therapies
Monoclonal antibody (mAb)

IgG1

15H2

Human

Human

ADCC-Enhanced anti-ACTN4 (15H2) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.

Cancer

Cancer