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Non-Fucosylated Anti-Human A33 (KRN330) Therapeutic Antibody (CAT#: BioBet-490ZP) Datasheet

Target
A33
Isotype
IgG1
Description
This is a non-fucosylated ADCC-enhanced anti-A33 (KRN330) therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.
Indication
Cancer; Colorectal Cancer
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced A33 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
A33
Full Name
Glycoprotein A33 (transmembrane)
Background
The glycoprotein encoded by this gene is a cell surface antigen that is expressed in greater than 95% of human colon cancers. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. The sequence of the extracellular region contains 2 domains characteristic of the CD2 subgroup of the immunoglobulin (Ig) superfamily.
Alternative Names
A33; glycoprotein A33 (transmembrane); GPA3
Gene ID
10223
UniProt ID
Q99795
Cellular Localization
Membrane
Involvement in Disease
Diseases associated with GPA33 include Foodborne Botulism and Wound Botulism.
Function
May play a role in cell-cell recognition and signaling.
Field of research
Cancer antibody; Metabolism antibody; Signaling Transduction antibody
Post-translational modifications
Highly N-glycosylated. Appears not to contain significant amounts of O-linked carbohydrates or sialic acid in its sugar moieties.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1
Antibody Clone
KRN330
Host
Human
Species Reactivity
Human
Description
KRN330 is a recombinant, fully-human monoclonal antibody directed against A33, a surface differentiation antigen on normal colonic epithelium, which is uniformly expressed in 95% of colorectal cancers.
Indication
Cancer; Colorectal Cancer

Cancer; Colorectal Cancer

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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