Book a Meeting

Non-fucosylated Anti-Human CEA (altumomab pentetate) Therapeutic Antibody (CAT#: BioBet-166ZP) Datasheet

Target
CEA
Isotype
IgG
Description
ADCC-enhanced altumomab pentetate is a non-fucosylated anti-CEA therapeutic biobetter antibody.
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced CEA antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CEA
Alternative Names
altumomab pentetate;hybri-ceaker;156586-92-4;ZCE 025;Hybri-ceaker;USP;indium In 111 altumomab pentetate;CEACAM1;carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein);BGP;BGP1;BGPI;antigen CD66;CD66a antigen;CEACAM3;carcinoembryo
Cellular Localization
Extracellular region or secreted Cytosol, Plasma membrane
Involvement in Disease
Diseases associated with CEACAM3 include Mucinous Cystadenocarcinoma and Polymorphous Low-Grade Adenocarcinoma.
Related Pathways
Its related pathways are Cell surface interactions at the vascular wall and Hematopoietic Stem Cells and Lineage-specific Markers.
Function
The main granulocyte receptors mediate the recognition of ceacam-binding microorganisms and effective opsonin-independent phagocytosis, including Neissiria, Moxarella and Haemophilus species, thereby playing an important role in the innate immune system in eliminating pathogens. It is responsible for the stimulation of RAC1 during the phagocytosis of pathogenic bacteria.
Post-translational modifications
Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
altumomab pentetate
Host
Mouse
Species Reactivity
Human
Description
Recombinant Mouse antibody to Human CEA. Indium (111In) altumomab pentetate (INN) (USP, indium In 111 altumomab pentetate; trade name Hybri-ceaker) is a mouse monoclonal antibody linked to pentetate which acts as a chelating agent for the radioisotope indium-111. The drug is used for the diagnosis of colorectal cancer

Related Products

Non-Fucosylated Anti-Human CEA (PR1A3) Therapeutic Antibody (CAT#: BioBet-1691ZP)
BetterBet™ Anti-CEA Recycling Antibody (CAT#: AES-0622-ZP15)
Highly Galactosylated Anti-CEA (altumomab pentetate) Antibody (CAT#: BioBet-GA-166ZP)
BetterBet™ Anti-CEA Half-Life Extended Antibody (CAT#: AES-0622-ZP999)
Non-Fucosylated Anti-Human CEA (5HFF12) Therapeutic Antibody (CAT#: BioBet-1692ZP)
BetterBet™ Anti-CEA On-Target Antibody (CAT#: AES-0622-ZP671)
BetterBet™ Anti-CEA FcγRIIB Binding Enhanced Antibody (CAT#: AES-0622-ZP343)

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

  • *
  • *
  • *
USA

UK

Germany