Non-Fucosylated Anti-Human Amyloid beta (BAN2401) Therapeutic Antibody (CAT#: BioBet-579ZP) Datasheet

APP

amyloid beta (A4) precursor protein

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

APP; Amyloid Beta; amyloid beta (A4) precursor protein

Plasma membrane, Extracellular region or secreted, Nucleus, Endosome

Diseases associated with APP include Cerebral Amyloid Angiopathy, App-Related and Alzheimer Disease.

Its related pathways are Neuroscience and Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways.

As a cell surface receptor, it performs physiological functions related to neurite growth, neuron adhesion, and axon formation on the surface of neurons. Interactions between APP molecules on adjacent cells promote synapse formation. Participate in cell migration and transcription regulation through protein interactions. Combined with G(O) and JIP-mediated apoptosis induction pathway. Inhibition of G(o)-atp enzyme activity (through similarity). As a kind of kinin I membrane receptor, it mediates the axonal transport of secretase and early protein 1 (similar). By acting as a kinesin I membrane receptor, it plays a role in the anterograde transport of axons to synapes. Participate in copper homeostasis/oxidative stress through the reduction of copper ions.

Cell Biology and Cellular Response antibody; Cell Death antibody; Developmental Biology antibody; Neuroscience antibody; Signaling Transduction antibody

Phosphorylation at Ser-410 by PKA severely impairs binding to OCRL.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG1

BAN2401

Humanized

Human

BAN2401 is a humanized IgG1 monoclonal antibody (mAb) that selectively binds to large soluble beta-amyloid protofibrils and is thought to enhance their clearance and/or neutralize their neurotoxicity. Soluble beta-amyloid oligomers and large protofibrils have been implicated in mediating neurotoxicity in Alzheimer's disease (AD).

Alzheimer's Disease

Alzheimer's Disease