Non-Fucosylated Anti-Human Progranulin (AG1) Therapeutic Antibody (CAT#: BioBet-955ZP) Datasheet

GRN

granulin

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.

GRN; granulin; GEP; GP88; PEPI; PGRN; CLN11; PCDGF; granulins; acrogranin; progranulin; proepithelin; granulin-epithelin; PC cell-derived growth factor

Extracellular region or secreted, Lysosome

Diseases associated with GRN include Ceroid Lipofuscinosis, Neuronal, 11 and Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-Related.

Its related pathways are Innate Immune System and Integrated Breast Cancer Pathway.

Secreted protein, which is a key regulator of lysosomal function and a growth factor involved in inflammation, wound healing and cell proliferation. Regulates protein transport to lysosomes and also regulates lysosomal enzyme activity. It also promotes the acidification of lysosomes, causing CTSB to degrade mature CTSD. In addition, as a wound-related growth factor, it directly acts on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures (similar). By blocking tnf-mediated neutrophil activation, preventing the release of oxidants and proteases, and promoting epithelial cell proliferation. In addition, it regulates inflammation in neurons by protecting neuron survival, axon growth and neuron integrity.

Cancer antibody; Immune System antibody; Neuroscience antibody

Granulins are disulfide bridged.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

AG1

Human

Human

This is a neutralizing anti-GP88 antibody, inhibits GP88 biological effect (proliferation and migration) in a dose-dependent fashion in vitro, used for treating breast cancer.

Cancer

Cancer