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Recombinant Human Fc Protein, IgG1 (CAT#: CB-P446-K) Datasheet

Product Type
Protein
Description
The Fc (Fragment, crystallizable) region, located in the base of the Y-shape antibody and composed of two heavy chains with two or three constant domains depending on the class of the antibody, binds to a specific class of Fc receptors and other immune molecules, such as complement proteins, to induce an appropriate immune response for a given antigen. The Fc region bears two highly conserved N-glycosylation sites, one on each heavy chain. The N-glycans attached to this site are predominantly core-fucosylated diantennary structures of the complex type. In addition, small amounts of these N-glycans also bear bisecting GlcNAc and α-2,6-linked sialic acid residues.

The recombinant human IgG1 Fc protein was produced in HEK 293 cells and purified by protein A.
Molecular weight: about 55 kDa.
Purity:>95% by SDS-PAGE under reducing conditions
Endotoxin Level: Less than 1 EU/ug of protein as determined by LAL method.
Formulation: 0.2 μM filtered solution of 200 mM HEPES, 100 mM NaCl, 50 mM NaOAc, pH 7.

Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
1 month from date of receipt, 2 to 8°C as supplied.
3 months from date of receipt, -20°C to -70°C as supplied.
Size
100 ug

All products and services are for Research Use Only. Do Not use in humans.

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Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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