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Non-fucosylated Anti-Human IL-5R (Benralizumab) Therapeutic Antibody (CAT#: BioBet-011ZP) Datasheet

ADCC-enhanced Benralizumab is a non-fucosylated anti-IL-5R therapeutic biobetter antibody.
Severe Eosinophilic Asthma
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced IL-5R antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
Full Name
interleukin 5 receptor subunit alpha
The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported.
Alternative Names
IL5RA; IL5R; Interleukin 5 Receptor Type 3; CDw125; CD125 Antigen; HSIL5R3; Interleukin 5 Receptor, Alpha; IL-5R Subunit Alpha; Interleukin-5 Receptor Alpha Chain; Interleukin-5 Receptor Subunit Alpha; IL-5RA; IL-5 Receptor Subunit Alpha
Gene ID
UniProt ID
Cellular Localization
Membrane; Single-pass type I membrane protein.
Involvement in Disease
Diseases associated with IL5RA include Disseminated Eosinophilic Collagen Disease and Hypereosinophilic Syndrome.
Related Pathways
Its related pathways are RET signaling and Signaling by GPCR.
This is the receptor for interleukin-5. The chain binds to IL5.
Post-translational modifications
1.Proteolytically processed under normal cellular conditions. 2.Proteolytically cleaved by caspases during neuronal apoptosis. Cleavage at Asp-739 by either caspase-6, -8 or -9 results in the production of the neurotoxic C31 peptide and the increased production of beta-amyloid peptides. 3. N- and O-glycosylated. 4. Neu5AcNeu5Ac is most likely Neu5Ac 2,8Neu5Ac linked. O-glycosylations in the vicinity of the cleavage sites may influence the proteolytic processing. Appicans are L-APP isoforms with O-linked chondroitin sulfate. 5. Phosphorylation in the C-terminal on tyrosine, threonine and serine residues is neuron-specific. 6. Extracellular binding and reduction of copper, results in a corresponding oxidation of Cys-144 and Cys-158, and the formation of a disulfide bond. In vitro, the APP-Cu(+) complex in the presence of hydrogen peroxide results in an increased production of beta-amyloid-containing peptides. 7. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). 8.Beta-amyloid peptides are degraded by IDE.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
Antibody Clone
Species Reactivity
Benralizumab is a humanized recombinant monoclonal antibody that targets the alpha chain of the interleukin 5 receptor (CD125) and was developed by MedImmune.
Severe Eosinophilic Asthma
Not Available

Benralizumab specifically binds to the alpha chain of interleukin 5 receptor (IL-5R) expressed on eosinophils and basophils. IL-5 induces eosinophil-mediated inflammatory responses by binding to the IL-5 receptor (IL-5R) expressed in eosinophils, basophils, and some mast cells. Therefore, the high affinity binding of Benralizumab to the alpha chain domain of IL-5R can block inflammatory signaling and the proliferation of IL-5 dependent cell lines.
Autoimmune diseases
Severe Eosinophilic Asthma

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All products and services are for Research Use Only. Do Not use in humans.


Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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