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Mouse Fc gamma RIV / CD16-2 Protein, His,Avi Tag (BLI verified) [Biotinylated] (CAT#: FC-P056-ZP) Datasheet

Product Type
Protein
Description
This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag.
The protein has a calculated MW of 24.6 kDa. The protein migrates as 30-40 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Species
Mouse
Conjugation
Biotin
Construction
It contains AA Gly 21 - Gln 203 (Accession # A0A0B4J1G0-1).
Expression
HEK293
N-Terminal
Predicted N-terminus: Gly 21
Tag
His Tag
Endotoxin
Less than 1.0 EU per μg by the LAL method.
Purity
>95% as determined by SDS-PAGE.
Buffer
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.
Target
Fc gamma RIV / CD16-2
Background
FcgR4(Low affinity immunoglobulin gamma Fc region receptor IV) is also known as CD16-2, FcgammaRIV, receptor for the Fc region of immunoglobulin gamma. Also acts as a receptor for the Fc region of immunoglobulin epsilon. Binds with intermediate affinity to both IgG2a and IgG2b. Does not display binding to IgG1 or IgG3. Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a. Binds with low affinity to both the a and b allotypes of IgE. Has also been shown to bind to IgE allotype a only but not to allotype b. Binding to IgE promotes macrophage-mediated phagocytosis, antigen presentation to T cells, production of proinflammatory cytokines and the late phase of cutaneous allergic reactions.
Alternative Names
Fc gamma RIV, CD16-2, Fcgr4

Figure 1 Molecular Characterization

Figure 2 SDS-PAGE

Figure 3 Bioactivity-BLI

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