Human Complement factor I Protein, Natural - 100 µg (CAT#: CB-P278-AB) Datasheet

Product Type
Protein
Description
Complement factor I (fI) is a protein of the complement system, first isolated in guinea pig serum, this protein regulates complement activation by lysing cell binding or liquid phases C3b and C4b. Due to the uncontrolled activation of the alternative pathway of complement, the lack of factor I in turn leads to a decrease in the level of complement component 3 (C3) in the plasma, and is associated with repeated bacterial infections in children. Recently, it has been shown that mutations in the factor I gene are related to the development of hemolytic uremic syndrome, which is also a kidney disease caused by unregulated complement activation.
Disease
Infectious diseases, Nephrology
Size
100 µg
Species
Human
Buffer
0.1 ml of approximately 1 mg/ml purified natural human Factor-I isolated from healthy blood donors, in Phosphate buffered saline, pH 7.2. The blood donors have been tested and found negative for various viruses (see table: Human blood test results). The exact protein concentration and functional activity is indicated on the label.
Application
Functional studies
Application Notes
For functional studies, the in vitro dilution must be optimized in the user's experimental setting.
Storage Instructions
Product should be stored at -80°C. Repeated freeze and thaw cycles will cause loss of activity. Use C5 protein within 31 hours after thawing and keep on ice. Remainder amounts should be aliquoted and immediately re-freezed for future use. Aliquots should never be thawed more than once. Under recommended storage conditions, product is stable for at least one year.
Target
Complement factor I
Alternative Names
CFI; AHUS3; ARMD13; C3BINA; C3b-INA; FI; IF; KAF; complement factor I

All products and services are for Research Use Only. Do Not use in humans.

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