Human C5L2 Peptide - 10 µg (CAT#: CB-P285-AB) Datasheet

Product Type
Protein
Description
The orphan receptor C5L2 (also known as gpr77), which has 35% amino identity with CD88, is a promiscuous complement fragment binding protein. C5L2 binds C5a with high affinity. Its affinity for C5a desArg is 10 times higher than that of CD88. C5L2 also has affinity for C4a and C3a and their metabolites C4a desArg and C3a desArg. C3a binds on a side different from the C5a binding site. Unlike other chemokine receptors, C5L2 has poor coupling ability with intracellular signaling and internalization mechanisms. The human C5L2 peptide is the N-terminal peptide (1-23).
Disease
Infectious diseases, Nephrology
Size
10 µg
Species
Human
Buffer
Lyophilized product in PBS containing 10 µg human C5L2. Reconstitute the vial by pipetting 0.1 ml distilled or de-ionised water (Caution: vial is under vacuum).
Application
Functional studies, Immuno assays, Western blot
Application Notes
For dilution, use protein-stabilized phosphate buffered saline, pH 7.4.
Storage Instructions
Product should be stored at -80°C. Repeated freeze and thaw cycles will cause loss of activity. Use C5 protein within 38 hours after thawing and keep on ice. Remainder amounts should be aliquoted and immediately re-freezed for future use. Aliquots should never be thawed more than once. Under recommended storage conditions, product is stable for at least one year.
Target
C5L2
Alternative Names
C5AR2; C5L2; GPF77; GPR77; complement component 5a receptor 2

All products and services are for Research Use Only. Do Not use in humans.

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