Human C3a des Arg Protein, Natural - 50 µg (CAT#: CB-P280-AB) Datasheet

Product Type
Protein
Description
C3 is the third part of the complement system and plays a central role in the complement cascade. In this key molecule, the three ways of compliment activation converge. Cleavage of the key complement component C3 leads to a set of effector molecules with multiple biological functions. The cleavage product C3b promotes complement activation and subsequent formation of membrane attack complexes. C3a, the small (about 10 kDa) lysate has allergic and immunomodulatory properties. It works through a specific receptor (C3aR), which belongs to the family of G protein coupled receptors. The expression of C3aR- in many cell types has been reported, including bone marrow cells and non-bone marrow cells. C3a is a protein of 74 amino acids. C3a itself has a short lifespan, and will quickly break down into more stable C3a-desArg (also known as acylation-stimulating protein, ASP) in the serum. It has been demonstrated that the expression of C3aR on hematopoietic stem/progenitor cells can promote the transport/homing of these cells to BM. The involvement of C3aR on DC and T cells has been shown to up-regulate the functions of these cells.
Disease
Infectious diseases, Nephrology
Size
50 µg
Species
Human
Buffer
0.1 ml of approximately 0.5 mg/ml purified natural human C3a desArg isolated from healthy blood donors, in Phosphate buffered saline, pH 7.2..The blood donors have been tested and found negative for various viruses (see table: Human blood test results). The exact protein concentration and functional activity is indicated on the label.
Application
Functional studies
Application Notes
For functional studies, the in vitro dilution must be optimized in the user's experimental setting.
Storage Instructions
Product should be stored at -80°C. Repeated freeze and thaw cycles will cause loss of activity. Use C5 protein within 33 hours after thawing and keep on ice. Remainder amounts should be aliquoted and immediately re-freezed for future use. Aliquots should never be thawed more than once. Under recommended storage conditions, product is stable for at least one year.
Target
C3a des Arg

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

  • *
  • *
  • *
USA

UK