Description
Anti-TSLP Antibody, Non-Fucosylated (BioBet-482ZP) is a human monoclonal IgG2, λ antibody against TSLP. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Asthma, Atopic dermatitis, Cat allergy
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced TSLP antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Full Name
TSLP Gene(Protein Coding)
Thymic Stromal Lymphopoietin
Background
This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Alternative Names
Tslp; thymic stromal lymphopoietin; TSLP; thymic stromal lymphopoietin
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with TSLP include Eczema Herpeticum and Allergic Asthma.
Related Pathways
Its related pathways are PEDF Induced Signaling and Development and heterogeneity of the ILC family.
Function
1.[Isoform 1]: Induces monocytes to release cytokines that attract t-cell chemokines, especially enhancing the maturation of CD11c(+) dendritic cells. It can directly activate mast cells to induce allergic inflammation. 2.[Isoform 2]: May be used as an antimicrobial peptide on the mouth and skin.
Post-translational modifications
1.Glycosylation at Asn119 and Asn64 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Clone
BioBet-482ZP
Description
ADCC-enhanced Tezepelumab is a non-fucosylated anti-TSLP therapeutic biobetter antibody.
Antibody Indication
Asthma, Atopic dermatitis, Cat allergy
