Description
Anti-Interleukin 2 Antibody, Non-Fucosylated (BioBet-1076ZP) is a humanized monoclonal IgG1 antibody against Interleukin 2. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Multiple Sclerosis; Rheumatoid Arthritis
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Interleukin 2 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Background
The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.
Alternative Names
IL2; interleukin 2; IL-2; TCGF; lymphokine; interleukin-2; aldesleukin; T cell growth factor; involved in regulation of T-cell clonal expansion
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with IL2 include Capillary Leak Syndrome and Tropical Spastic Paraparesis.
Related Pathways
Its related pathways are RET signaling and Signaling by GPCR.
Function
This protein is produced by T cells under antigen or mitotic stimulation and is required for T cell proliferation and other important activities that regulate immune responses. It can stimulate b cells, monocytes, lymphocytes to activate killer cells, natural killer cells, and glioma cells.
Post-translational modifications
1.Glycosylation at Thr23 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Clone
BioBet-1076ZP
Description
MT204 is a humanized IgG1 antibody specific for interleukin-2 (IL-2) of human and rhesus monkey origin. MT204 has the potential to treat a wide variety of acute and chronic inflammatory diseases, including rheumatoid arthritis, asthma, acute transplant rejection, uveitis, psoriasis and multiple sclerosis. MT204 is the first humanized antibody targeting soluble human and non-human primate IL-2 by a unique mode of action, and has been shown in preclinical models to have inhibitory properties.
Antibody Indication
Multiple Sclerosis; Rheumatoid Arthritis
