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Anti-Integrin alpha 10 Antibody, Non-Fucosylated (BioBet-1128ZP) (CAT#: BioBet-1128ZP) Datasheet

Target
Integrin alpha 10
Isotype
IgG2a
Description
Anti-Integrin alpha 10 Antibody, Non-Fucosylated (BioBet-1128ZP) is a humanized monoclonal IgG2a antibody against Integrin alpha 10. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Joint Diseases
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Integrin alpha 10 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
ITGA10
Full Name
integrin, alpha 10
Background
Integrins are integral transmembrane glycoproteins composed of noncovalently linked alpha and beta chains. They participate in cell adhesion as well as cell-surface mediated signalling. This gene encodes an integrin alpha chain and is expressed at high levels in chondrocytes, where it is transcriptionally regulated by AP-2epsilon and Ets-1. The protein encoded by this gene binds to collagen. Alternative splicing results in multiple transcript variants.
Alternative Names
ITGA10; integrin, alpha 10; PRO827; integrin alpha-10
Gene ID
8515
Cellular Localization
Membrane
Involvement in Disease
Diseases associated with ITGA10 include Colon Mucinous Adenocarcinoma.
Related Pathways
Its related pathways are Integrin Pathway and Degradation of the extracellular matrix.
Function
Integrin alpha-10/beta-1 is a receptor for collagen.
Post-translational modifications
1.Glycosylation at Asn234, Asn98, Asn336, Asn364, Asn733, Asn763, Asn839, Asn921, Asn1011, Asn1018, and Asn1039 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG2a
Antibody Clone
BioBet-1128ZP
Host
Humanized
Species Reactivity
Human
Description
This is a monoclonal antibody binding to the extracellular I-domain of integrin alpha10beta1 and can be used for different diseases related to joints, cartilage and atherosclerosis.
Antibody Indication
Joint Diseases

Joint Diseases

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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