Anti-IL17RC Antibody, Non-Fucosylated (BioBet-1062ZP) (CAT#: BioBet-1062ZP) Datasheet

IL17RC

interleukin 17 receptor C

This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling.

IL17RC; interleukin 17 receptor C; IL17RL; IL17-RL; interleukin-17 receptor C; IL-17RL; IL17Rhom; zcytoR14; IL17F receptor; IL-17 receptor C; interleukin-17 receptor homolog; interleukin-17 receptor-like protein

Plasma membrane

Diseases associated with IL17RC include Candidiasis, Familial, 9 and Chronic Mucocutaneous Candidiasis.

Its related pathways are IL-17 Family Signaling Pathways and Akt Signaling.

Receptor for IL17A and IL17F homodimers, as part of the heterodimer with IL17RA. As part of the heterodimer with IL17RA, IL17A and IL17B form a heterodimer receptor. It has also been proven to be a homologous receptor for IL17F, which can bind to IL17A with high affinity without the need for IL17RA. The activation of IL17RC induces the expression of inflammatory chemokines and cytokines such as CXCL1.

1.Glycosylation at Asn189, Asn257, Asn284, Asn297, Asn324, Asn334, Asn420, Asn443, and Asn477 2.Modification sites at PhosphoSitePlus 3.Ubiquitination at Lys572

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

BioBet-1062ZP

Mouse

Human

IL-17C is a cytokine that is involved in inflammatory processes and human disease. IL-17RE is a receptor for IL-17C. The anti-IL-17RE antibody are useful in blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17C.

Inflammatory Diseases

Inflammatory Diseases