Product Type
Fc Silent Antibody
Description
Anti-Human NKG2A-Fc silent antibody is a Humanized monoclonal antibody targeting the ICOS. And it is intended for the research of Head and neck squamous cell carcinoma .
Research Area
Cell Biology, Immunology
Antigen Distribution
Broad expression in spleen (RPKM 1.5), endometrium (RPKM 1.3) and 21 other tissues.
Disease
Head and neck cancer
Size
100 ug
Species
Human
Clonality
Monoclonal
Conjugation
Unconjugated
Source
Recombinant
Buffer
PBS, pH 7.4
Application Notes
The use of diluent depends on the detection system used. It is recommended that users test reagents and determine their own optimal dilution.
Handling Advice
This product is for research use only. It is not intended for use in therapeutic or diagnostic procedures for humans or animals.
Storage Instructions
Product should be stored at -80°C. Repeated freeze and thaw cycles will cause loss of activity. Use product within 24 hours after thawing and keep on ice. Remainder amounts should be aliquoted and immediately re-freezed for future use. Aliquots should never be thawed more than once. Under recommended storage conditions, product is stable for at least one year.
Official Name
NKG2A
Full Name
Killer cell lectin like receptor C1
Background
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jan 2015]
Alternative Names
NKG2; NKG2A; CD159A; KLRC1; killer cell lectin like receptor C1
Gene ID
3821
Uniprot ID
P26715
