Product Type
Antibody
Description
Mannose binding lectin (MBL) also known as mannose or mannan binding protein (MBP) is a member of the collectins group. MBL is an oligolectin that can recognize carbohydrates as mannose and N-acetylglucosamine on pathogens. MBL contains a recognition domain rich in cysteine, similar to collagen and carbohydrates. It forms a complex with C1r/C1, such as the serine protease MASP, which cleaves C4, C2, and C3 through proteolysis. MBL can activate the complement pathway independently of the classical and alternative complement activation pathways. The MBL-MASP pathway (more called the lectin pathway) is independent of antibodies and C1q. MBL exhibits complement-dependent antibacterial activity and directly acts as a conditioning agent, so it plays an important role in innate immunity. MBL is synthesized by liver cells and has been isolated from the liver or serum of various vertebrates.
Disease
Infectious diseases
Size
100 µg
Immunogen
Serum isolated human RaRF
Species
Human
Clonality
Monoclonal
Clone Number
3E7
Buffer
PBS, containing 1% bovine serum albumin and 0.02% sodium azide.
Application
Flow cytometry, Frozen sections, Functional studies, Immuno assays
Application Notes
The diluent used depends on the detection system used. It is recommended that users test reagents and determine their own optimal dilution. The typical initial working dilution is 1:50. For functional studies, the in vitro dilution must be optimized in the user's experimental setting.
Storage Instructions
Product should be stored at 4°C. Under recommended storage conditions, product is stable for at least one year.
Alternative Names
Mannan Binding Lectin; mannose- or mannan-binding protein; MBP
