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Creative Biolabs - ADCC+ Antibody

Anti-GLP-1 Antibody, Non-Fucosylated (BioBet-928ZP) (CAT#: BioBet-928ZP) Datasheet

Target
GLP-1
Isotype
IgG
Description
Anti-GLP-1 Antibody, Non-Fucosylated (BioBet-928ZP) is a human monoclonal IgG antibody against GLP-1. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Metabolic Disorders
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced GLP-1 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
GLP-1
Full Name
golgi glycoprotein 1
Background
Glucagon-like peptide-1 (GLP-1) is an incretin derived from the transcription product of the proglucagon gene. The major source of GLP-1 in the body is the intestinal L cell that secretes GLP-1 as a gut hormone. The biologically active forms of GLP-1 are: GLP-1-(7-37) and GLP-1-(7-36)NH2. Those peptides result from selective cleavage of the proglucagon molecule.
Alternative Names
Glucagon-like peptide 1; GLP-1
UniProt ID
Q9UK05
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with GLP1R include Insulinoma and Hyperglycemia.
Related Pathways
Its related pathways are Integration of energy metabolism and Signaling by GPCR.
Function
Glucagon-like peptide 1 g protein-coupled receptor (GLP-1). Ligand binding triggers the activation of the signal cascade, leading to the activation of adenyl cyclase and the increase of intracellular cAMP levels. Regulates insulin secretion in the GLP-1 response (similar).
Post-translational modifications
N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-928ZP
Host
Human
Species Reactivity
Human
Description
The antibody that bind to Glucagon-like peptide 1 (GLP-I) are using for treating metabolic disorders, enhancing insulin expression, and promoting insulin secretion.
Antibody Indication
Metabolic Disorders

Metabolic Disorders

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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