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Anti-CGRP Receptor Antibody, Non-Fucosylated (AMG 334) (CAT#: BioBet-623ZP) Datasheet

Target
Calcitonin gene-related peptide Receptor
Isotype
IgG
Description
Anti-CGRP Receptor Antibody, Non-Fucosylated (BioBet-623ZP) is a human monoclonal IgG antibody against Calcitonin gene-related peptide Receptor. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Migraine
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Calcitonin gene-related peptide Receptor antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CALCRL
Full Name
calcitonin receptor-like
Alternative Names
CALCRL; calcitonin receptor-like; CRLR; CGRPR; calcitonin gene-related peptide type 1 receptor; CGRP type 1 receptor; calcitonin receptor-like receptor
Gene ID
10203
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with CALCRL include Lymphatic Malformation 8 and Primary Angle-Closure Glaucoma.
Related Pathways
Its related pathways are Signaling by GPCR and G alpha (s) signalling events.
Function
Calcitonin gene-related peptide (CGRP) receptor and RAMP1, adrenomedullin receptor and RAMP3 (similar). Adrenomedullin receptor and RAMP2. The activity of this receptor is mediated by the G protein that activates adenosine cyclase.
Post-translational modifications
1.Glycosylation at Asn66, Asn118, and Asn123 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
AMG 334
Host
Human
Species Reactivity
Human
Description
AMG 334 is a fully human monoclonal antibody under investigation for the prevention of migraine by inhibiting the calcitonin gene-related peptide (CGRP) receptor that is believed to transmit signals that can cause incapacitating pain.
Antibody Indication
Migraine

Migraine

Related Products

Anti-CGRP Receptor Antibody, FcγRIIB Binding Enhanced (AES-0622-ZP592) (CAT#: AES-0622-ZP592)
Anti-CGRP Receptor Antibody, Half-Life Extended (AES-0622-ZP1248) (CAT#: AES-0622-ZP1248)
Anti-CGRP Receptor Antibody, On-Target (AES-0622-ZP920) (CAT#: AES-0622-ZP920)
Anti-CGRP Receptor Antibody, Recycling (AES-0622-ZP264) (CAT#: AES-0622-ZP264)

All products and services are for Research Use Only. Do Not use in humans.

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Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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