Description
Non-Fucosylated Anti-Human CD20 (Ublituximab) is a glycosylation-modified therapeutic biobetter antibody.
Antibody Indication
Various forms of B-cell associated lymphomas; Chronic Lymphocytic Leukemia; Chronic Lymphocytic Leukemia, Non-Hodgkin's Lymphoma; Non-Hodgkin Lymphoma, B-cell Lymphoma, Waldenstrom's Macroglobulinemia, Marginal Zone Lymphoma, Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Primary Central Nervous System Lymphoma; Neuromyelitis Optica, Neuromyelitis Optica Spectrum Disorder; Chronic Lymphocytic Leukemia, Mantle Cell Lymphoma; Multiple Sclerosis; Diffuse Large B-Cell, Lymphoma Follicular Lymphoma, Marginal Zone Lymphoma, Small Lymphocytic Lymphoma; Chronic Lymphocytic Leukemia; Relapsing Multiple Sclerosis (RMS);
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced CD20 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
MS4A1
Full Name
membrane spanning 4-domains A1
Background
This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein.
Alternative Names
B1; S7; Bp35; CD20; CVID5; MS4A2; LEU-16
Gene ID
931
UniProt ID
P11836
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
Ublituximab
Description
Non-Fucosylated Anti-Human CD20 (Ublituximab) is a glycosylation-modified therapeutic biobetter antibody.
Antibody Indication
Various forms of B-cell associated lymphomas; Chronic Lymphocytic Leukemia; Chronic Lymphocytic Leukemia, Non-Hodgkin's Lymphoma; Non-Hodgkin Lymphoma, B-cell Lymphoma, Waldenstrom's Macroglobulinemia, Marginal Zone Lymphoma, Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Primary Central Nervous System Lymphoma; Neuromyelitis Optica, Neuromyelitis Optica Spectrum Disorder; Chronic Lymphocytic Leukemia, Mantle Cell Lymphoma; Multiple Sclerosis; Diffuse Large B-Cell, Lymphoma Follicular Lymphoma, Marginal Zone Lymphoma, Small Lymphocytic Lymphoma; Chronic Lymphocytic Leukemia; Relapsing Multiple Sclerosis (RMS);
