Book a Meeting

Anti-CD2 Siplizumab Antibody, a Fc Silent Biobetter (CAT#: FCS-108P) Datasheet

Product Type
Fc Silent Antibody
Description
The antibody Fc domain is responsible for the function in the antibody, while the Fab domain is responsible for targeting. Therefore, Fc engineering represents the engineering function of antibodies, which are effector functions, such as antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP), and control the serum half-life. Therefore, Fc engineering for immune silencing or further protein engineering is essential for immune cell binding to antibodies.

The Fc-silenced antibody provided by Creative Biolabs contains key point mutations that eliminate the binding of Fc receptors (FcγR, FcR), thereby eliminating the cytotoxic (ADCC) effector function of the antibody.
Species
Human
Clonality
Monoclonal
Isotype
Human IgG1, κ
Clone Number
Siplizumab
Conjugation
Unconjugated
Source
Recombinant
Buffer
PBS, pH 7.4
Application
Funcs, In vivo assay
Application Notes
The use of diluent depends on the detection system used. It is recommended that users test reagents and determine their own optimal dilution.
Storage Instructions
Product should be stored at -20°C. Repeated freeze and thaw cycles will cause loss of activity. Use product within 24 hours after thawing and keep on ice. Remainder amounts should be aliquoted and immediately re-freezed for future use. Aliquots should never be thawed more than once. Under recommended storage conditions, product is stable for at least one year.
Target
CD2
Official Name
CD2
Full Name
CD2 Molecule
Background
CD2 (CD2 Molecule) is a Protein Coding gene.
Diseases associated with CD2 include Penis Squamous Cell Carcinoma and Immune Defect Due To Absence Of Thymus.
Among its related pathways are PEDF Induced Signaling and Akt Signaling.
Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and receptor activity.
Alternative Names
Siplizumab; 288392-69-8; MEDI-507; CD2; CD2 molecule; CD2 antigen (p50), sheep red blood cell receptor, SRBC; T-cell surface antigen CD2; LFA-3 receptor; rosette receptor; erythrocyte receptor; lymphocyte-function antigen-2; T-cell surface antigen T11/Leu-5;
Gene ID
914
Uniprot ID
P06729

Related Products

Anti-Human CD2 Fc Silent Antibody, Clone hSC16 (CAT#: CB-LX008-A)
Anti-CD154 [IDEC-131 (Toralizumab)] Fc Silent Antibody, Human IgG1 kappa (CAT#: BioBet-F507P)
Anti-CD154 [IDEC-131 (Toralizumab)] Fc Silent Antibody, Mouse IgG2b kappa (CAT#: BioBet-F506P)
Anti-CD19 [CAT-13.1E10] Fc Silent Antibody, Human IgG1 kappa (CAT#: BioBet-F504P)
Anti-CD19 [FMC63] Fc Silent Antibody, Mouse IgG2a kappa (CAT#: BioBet-F505P)
Anti-CD151 [11G5a] Fc Silent Antibody, Human IgG1 kappa (CAT#: BioBet-F510P)
Anti-CD153 [RM153] Fc Silent Antibody, Mouse IgG2a kappa (CAT#: BioBet-F508P)

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

  • *
  • *
  • *
USA

UK

Germany

ISO 9001 Certified - Creative Biolabs Quality Management System.