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Anti-Cadherin-19 Antibody, Non-Fucosylated (BioBet-766ZP) (CAT#: BioBet-766ZP) Datasheet

Target
Cadherin-19
Isotype
IgG
Description
Anti-Cadherin-19 Antibody, Non-Fucosylated (BioBet-766ZP) is a human monoclonal IgG antibody against Cadherin-19. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Melanoma
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Cadherin-19 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
DCHS1
Full Name
dachsous cadherin-related 1
Background
This gene is a member of the cadherin superfamily whose members encode calcium-dependent cell-cell adhesion molecules. The encoded protein has a signal peptide, 27 cadherin repeat domains and a unique cytoplasmic region. This particular cadherin family member is expressed in fibroblasts but not in melanocytes or keratinocytes. The cell-cell adhesion of fibroblasts is thought to be necessary for wound healing.
Alternative Names
DCHS1; dachsous cadherin-related 1; FIB1; CDH19; CDH25; CDHR6; PCDH16; VMLDS1; Cadherin-19; Cadherin 19; Protein dachsous homolog 1; protocadherin-16; protocadherin 16; cadherin-25; cadherin 25; fibroblast cadherin-1; fibroblast cadherin
Gene ID
8642
UniProt ID
Q96JQ0
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with DCHS1 include Van Maldergem Syndrome 1 and Mitral Valve Prolapse 2.
Related Pathways
Its related pathways are ERK Signaling and Hippo signaling pathway - multiple species.
Function
Calcium-dependent enzyme protein. Mediates the proliferation and differentiation of neural progenitor cells. In the heart, it plays a key role in the normal morphology of the mitral valve and regulates the migration of cells involved in the process of valve formation.
Post-translational modifications
1.Glycosylation at Asn217, Asn256, Asn402, Asn584, Asn1249, Asn1521, Asn1718, Asn1996, Asn2361, Asn2428, Asn2569, Asn2761, Asn2792, and Asn2862 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-766ZP
Host
Human
Species Reactivity
Human
Description
This is a human antibody capable of binding to human CDH19 on the surface of a target cell, it can be used for the treatment or amelioration of a melanoma disease or metastatic melanoma disease.
Antibody Indication
Melanoma

Melanoma

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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