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Anti-Antithrombin Beta Antibody, Non-Fucosylated (TPP2803) (CAT#: BioBet-1279ZP) Datasheet

Target
Antithrombin Beta
Isotype
IgG1
Description
ADCC-Enhanced anti-Antithrombin Beta (TPP2803) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.
Antibody Indication
Hemophilia
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Antithrombin Beta antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
SERPINC1
Full Name
serpin peptidase inhibitor, clade C (antithrombin), member 1
Background
The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency.
Alternative Names
SERPINC1; serpin peptidase inhibitor, clade C (antithrombin), member 1; AT3; AT3D; ATIII; THPH7; Antithrombin
Gene ID
462
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with SERPINC1 include Antithrombin Iii Deficiency and Thrombosis.
Related Pathways
Its related pathways are Formation of Fibrin Clot (Clotting Cascade) and Response to elevated platelet cytosolic Ca2+.
Function
The most important serine protease inhibitor that regulates the coagulation cascade in plasma. AT-III can inhibit thrombin, matriptase-3/TMPRSS7 and factors IXa, Xa and XIa. In the presence of heparin, its inhibitory activity is greatly enhanced.
Post-translational modifications
Phosphorylated by FAM20C in the extracellular medium.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1
Antibody Clone
TPP2803
Host
Human
Species Reactivity
Human
Description
The antibody directed against human antithrombin β complexed with heparin and/or heparin-like structure (ATβH). The antibodys are used to treat hemophilia.
Antibody Indication
Hemophilia

Hemophilia

Related Products

Anti-Antithrombin Beta Antibody, Non-Fucosylated (TPP2009) (CAT#: BioBet-1278ZP)

All products and services are for Research Use Only. Do Not use in humans.

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Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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