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Non-fucosylated Anti-Human IFN alpha (Rontalizumab) Therapeutic Antibody (CAT#: BioBet-263ZP) Datasheet

Target
IFN alpha
Isotype
IgG1, κ
Description
ADCC-enhanced Rontalizumab is a non-fucosylated anti-IFN alpha therapeutic biobetter antibody.
Indication
Systemic lupus erythematosus (SLE)
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced IFN alpha antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
IFNA1
Full Name
Interferon Alpha 1
Background
The protein encoded by this gene is produced by macrophages and has antiviral activity. This gene is intronless and the encoded protein is secreted. [provided by RefSeq, Sep 2011]
Alternative Names
Rontalizumab;948570-30-7;rhuMAb IFN alpha;RG7415;IFNA1;interferon, alpha 1;interferon alpha-1/13;IFL;IFN;IFN ALPHA;IFN alpha 1b;IFN alphaD;IFNA13;IFNA@;interferon alpha 1b;leIF D;IFN-alpha 1b;IFN-alpha-1/13;interferon-alpha1;interferon alpha-D;IFN-ALPHA;I
Gene ID
3439
UniProt ID
P01562
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with IFNA1 include Hepatitis and Viral Infectious Disease.
Related Pathways
Its related pathways are all-trans-Retinoic Acid Mediated Apoptosis and Tuberculosis.
Function
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
Post-translational modifications
1.Modification sites at PhosphoSitePlus 2.Modification sites at neXtProt
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1, κ
Antibody Clone
Rontalizumab
Host
Humanized
Species Reactivity
Human
Description
Recombinant monoclonal antibody to IFN alpha. Rontalizumab is a humanized monoclonal antibody. for treatment of systemic lupus erythematosus.
Indication
Systemic lupus erythematosus (SLE)

Systemic lupus erythematosus (SLE)

Related Products

BetterBet™ Anti-IFN alpha Recycling Antibody (CAT#: AES-0622-ZP300)
Highly Galactosylated Anti-IFN alpha (Rontalizumab) Antibody (CAT#: BioBet-GA-263ZP)
BetterBet™ Anti-IFN alpha FcγRIIB Binding Enhanced Antibody (CAT#: AES-0622-ZP628)
BetterBet™ Anti-IFN alpha On-Target Antibody (CAT#: AES-0622-ZP956)
BetterBet™ Anti-IFN alpha Half-Life Extended Antibody (CAT#: AES-0622-ZP1284)

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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