Non-fucosylated Anti-Human NGF (Frunevetmab) Therapeutic Antibody (CAT#: BioBet-395ZP) Datasheet

NGF

Nerve Growth Factor

This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008]

Nerve growth factor; nerve growth factor beta polypeptide; NGFB; beta-NGF

Extracellular region or secreted, Endosome

Diseases associated with NGF include Neuropathy, Hereditary Sensory And Autonomic, Type V and Autonomic Neuropathy.

Its related pathways are Neuroscience and NGF Pathway.

Nerve growth factor is very important for the development and maintenance of the sympathetic and sensory nervous systems. The extracellular ligands of NTRK1 and NGFR receptors activate the cell signaling cascade to regulate the proliferation, differentiation and survival of neurons. Immature NGF precursor (proNGF) acts as a ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cells that cause RAC1 and/or RAC2 inactivation, actin cytoskeleton reorganization, and neuronal growth cone collapse Signal cascade. Compared to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (similar). Inhibit metalloproteinase-dependent proteolysis of platelet glycoprotein VI. Lysophosphatidylinositol and lysophosphatidylserine bind between the two chains of the homodimer. The lipid-bound form promotes histamine re-enzyme from mast cells, in contrast to the lipid-free form (due to the similarity). 发送反馈 历史记录

Neuroscience antibody; Signaling Transduction antibody

1.Glycosylation at Ser43, Thr46, Asn69, and Asn114 2.Modification sites at PhosphoSitePlus

Protein Based Therapies
Monoclonal antibody (mAb)

IgG1, κ

Frunevetmab

Felinized

Feline

ADCC-enhanced Frunevetmab is a non-fucosylated anti-NGF therapeutic biobetter antibody.

Pain chronic

Pain chronic