Non-fucosylated Anti-Human TGFB1 (Fresolimumab) Therapeutic Antibody (CAT#: BioBet-454ZP) Datasheet

TGFB1

TGFB1 Gene(Protein Coding)


Transforming Growth Factor Beta 1

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease. [provided by RefSeq, Aug 2016]

Fresolimumab; 948564-73-6; GC1008; GC1008; TGFB1; transforming growth factor, beta 1; DPD1, TGFB; transforming growth factor beta-1; Camurati Engelmann disease; CED; TGFbeta; TGF-beta-1; TGF-beta 1 protein; latency-associated peptide; LAP; DPD1; TGFB;

Extracellular region or secreted

Diseases associated with TGFB1 include Camurati-Engelmann Disease and Inflammatory Bowel Disease, Immunodeficiency, And Encephalopathy.

Its related pathways are Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway and Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer.

1.Transforming growth factor-1 preprotein: Delay associated peptide (LAP) and transforming growth factor-1 (tgf-1) chain precursors, which constitute the regulatory and active subunits of tgf-1, respectively. 2.It is necessary to store the transforming growth factor-1 (tgf-1) chain in the latent state in the extracellular matrix. It is non-covalently associated with tgf -1 and regulates its activation by interacting with "environmental molecules" that control tgf -1 activation. The interaction with LRRC33/NRROS regulates the activation of tgf-1 in macrophages and microglia (possibly). The interaction with LRRC32/GARP controls the activation of tgf-1 on the surface of activated regulatory T cells (Tregs). The interaction with integrins (ITGAV:ITGB6 or ITGAV:ITGB8) leads to delayed distortion of the related peptide chain and subsequent release of active tgf-1. 3.Transforming growth factor-1: a multifunctional protein that regulates the growth and differentiation of various cell types, and participates in various processes such as normal development, immune function, microglia function, and response to neurodegeneration (through similarity) .

Cancer antibody; Cell Biology and Cellular Response antibody; Developmental Biology antibody; Metabolism antibody; Signaling Transduction antibody

Glycosylated. The precursor is cleaved into mature TGF-beta-1 and LAP, which remains non-covalently linked to mature TGF-beta-1 rendering it inactive.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG4, κ

Fresolimumab

Human

Human

ADCC-enhanced Fresolimumab is a non-fucosylated anti-TGFB1 therapeutic biobetter antibody.

Idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis