Non-Fucosylated Anti-Human TrkC (6.1.2) Therapeutic Antibody - Creative Biolabs
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Non-Fucosylated Anti-Human TrkC (6.1.2) Therapeutic Antibody (CAT#: BioBet-1487ZP) Datasheet

Target
TrkC
Isotype
IgG
Description
ADCC-Enhanced anti-TrkC ( 6.1.2) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.
Indication
Nerve Cell Damage
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced TrkC antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
NTRK3
Full Name
neurotrophic tyrosine kinase, receptor, type 3
Background
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Alternative Names
NTRK3; neurotrophic tyrosine kinase, receptor, type 3; TRKC; gp145(trkC); NT-3 growth factor receptor; GP145-TrkC; ETV6-NTRK3 fusion; tyrosine kinase receptor C; ETS related protein-neurotrophic receptor tyrosine kinase fusion protein;
Gene ID
Cellular Localization
Membrane
Involvement in Disease
Diseases associated with NTRK3 include Fibrosarcoma and Congenital Mesoblastic Nephroma.
Related Pathways
Its related pathways are Neuroscience and Guidance Cues and Growth Cone Motility.
Function
Receptor tyrosine kinases are involved in the nervous system and possibly heart development. After NTRK3 binds to the ligand NTF3/neurotrophin-3, it autophosphorylates and activates different signaling pathways, including phosphatidylinositol 3-kinase/AKT and MAPK pathways, which control cell survival and differentiation.
Post-translational modifications
Ligand-mediated auto-phosphorylation.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
6.1.2
Host
Mouse
Species Reactivity
Human
Description
The anli-trkC monoelonal antoihodies are involved in treatment of nerve cell damage associated with acute nervous cell system initiry and chronic neutrodcgenerative diseaises.
Indication
Nerve Cell Damage

Nerve Cell Damage

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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