Anti-RAGE Antibody, Non-Fucosylated (BioBet-541ZP) (CAT#: BioBet-541ZP) Datasheet

AGER

advanced glycosylation end product-specific receptor

The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimers disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847).

AGER; advanced glycosylation end product-specific receptor; RAGE; RAGE isoform sRAGE-delta; RAGE isoform NtRAGE-delta; receptor for advanced glycation end-products variant 20

Nucleus

Diseases associated with AGER include Diabetic Angiopathy and Leukostasis.

Its related pathways are amb2 Integrin signaling and Activated TLR4 signalling.

Mediates the interaction of advanced glycation end products (AGE). These non-enzymatic glycosylated proteins accumulate in blood vessel tissues during aging, and accumulate at an accelerated rate in diabetes. As a mediator of acute and chronic vascular inflammation, such as atherosclerosis, especially a complication of diabetes. Age/anger signals play an important role in regulating the production/expression of tnf -, oxidative stress and endothelial dysfunction in type 2 diabetes. The interaction with S100A12 on endothelial cells, monocytes, and lymphocytes triggers cell activation and produces key pro-inflammatory mediators. The interaction with S100B after myocardial infarction may participate in cardiomyocyte apoptosis by activating ERK1/2 and p53/TP53 signaling pathways (similarities). Amyloid peptide receptor. In cortical neurons, amyloid-peptide (ABPP) is transferred from the outside of the cell to the inside of the cell through the cell membrane. The anger signal initiated by ABPP, especially the stimulation of p38 mitogen-activated protein kinase (MAPK), has the ability to drive a transport system that transmits ABPP as an anger complex to the inner space of the nerve. Can also bind oligonucleotides.

1.Glycosylation at Asn25 and Asn81 2.Modification sites at PhosphoSitePlus

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

BioBet-541ZP

Humanized

Human

The antibodys have the ability to inhibit the binding of RAGE to its various ligands. The antibody or portions thereof of described in the present application are useful for treating a disease or disorder characterized by or induced by pathophysiological ligands of RAGE, for example missfolded proteins like amyloid β and advanced glycation-end-products.

Inflammatory Diseases

Inflammatory Diseases