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Non-Fucosylated Anti-Human PDGFB (AbyD3263) Therapeutic Antibody, an ADCC-Enhanced Biobetter (CAT#: BioBet-1495ZP) Datasheet

Mouse IgG
ADCC-Enhanced anti-PDGFB (AbyD3263) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform. By reducing the fucosylation of the Fc region, the ADCC-enhanced antibody shows an increased binding affinity for the FcyR receptor on immune effector cells.
More specifically, the afucosylated therapeutic biobetter antibody was generated by recombinant DNA technology. It has been produced in CHO cells that are deficient for fucosylation and purified by affinity chromatography with protein G. The absence of the fucose residue from the N-glycans of IgG-Fc results in dramatic enhancement of antibody-dependent cellular cytotoxicity (ADCC).
Biliary Fibrosis; Liver Disease
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced rituximab. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
Full Name
platelet-derived growth factor beta polypeptide
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2013]
Alternative Names
PDGFB; platelet-derived growth factor beta polypeptide; SIS; SSV; IBGC5; PDGF2; c-sis; PDGF-2; platelet-derived growth factor subunit B; becaplermin; PDGF, B chain; PDGF subunit B; proto-oncogene c-Sis; platelet-derived growth factor 2; platelet-derived growth factor B chain; platelet-derived growth factor, beta polypeptide (oncogene SIS); platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog);
Gene ID
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with PDGFB include Dermatofibrosarcoma Protuberans and Basal Ganglia Calcification, Idiopathic, 5.
Related Pathways
Its related pathways are RET signaling and Phospholipase D signaling pathway.
Growth factors that play an important role in embryonic development, cell proliferation, cell migration, survival and chemotaxis. A potent mitogen for cells of mesenchymal origin. It is necessary for the normal proliferation and replenishment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lungs, heart and placenta. This is necessary for normal blood vessel development and glomerular development. Play an important role in wound healing. The signal is regulated (by similarity) by the formation of heterodimers of PDGFA.
Post-translational modifications
1.Glycosylation at Asn63 and Thr190) 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
Mouse IgG
Antibody Clone
Species Reactivity
MOR8457 is a PDGF-BB monoclonal antibody, binds to PDGF-BB with high affinity and selectivity, and used for biliary fibrosis in patients with liver disease.
Biliary Fibrosis; Liver Disease

Biliary Fibrosis; Liver Disease

All products and services are for Research Use Only. Do Not use in humans.


Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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