Non-Fucosylated Anti-Human PDGFB (AbyD3263) Therapeutic Antibody (CAT#: BioBet-1495ZP) Datasheet

PDGFB

platelet-derived growth factor beta polypeptide

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2013]

PDGFB; platelet-derived growth factor beta polypeptide; SIS; SSV; IBGC5; PDGF2; c-sis; PDGF-2; platelet-derived growth factor subunit B; becaplermin; PDGF, B chain; PDGF subunit B; proto-oncogene c-Sis; platelet-derived growth factor 2; platelet-derived growth factor B chain; platelet-derived growth factor, beta polypeptide (oncogene SIS); platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog);

Extracellular region or secreted

Diseases associated with PDGFB include Dermatofibrosarcoma Protuberans and Basal Ganglia Calcification, Idiopathic, 5.

Its related pathways are RET signaling and Phospholipase D signaling pathway.

Growth factors that play an important role in embryonic development, cell proliferation, cell migration, survival and chemotaxis. A potent mitogen for cells of mesenchymal origin. It is necessary for the normal proliferation and replenishment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lungs, heart and placenta. This is necessary for normal blood vessel development and glomerular development. Play an important role in wound healing. The signal is regulated (by similarity) by the formation of heterodimers of PDGFA.

1.Glycosylation at Asn63 and Thr190) 2.Modification sites at PhosphoSitePlus

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

AbyD3263

Mouse

Human

MOR8457 is a PDGF-BB monoclonal antibody, binds to PDGF-BB with high affinity and selectivity, and used for biliary fibrosis in patients with liver disease.

Biliary Fibrosis; Liver Disease

Biliary Fibrosis; Liver Disease