Non-Fucosylated Anti-Human Integrin αL (BioBet-1134ZP) Therapeutic Antibody (CAT#: BioBet-1134ZP) Datasheet

ITGAL

integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)

ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene.

ITGAL; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide); CD11A; LFA-1; LFA1A; integrin alpha-L; LFA-1A; LFA-1 alpha; integrin gene promoter; CD11 antigen-like family member A; lymphocyte function-associated antigen 1; leukocyte adhesion glycoprotein LFA-1 alpha chain; leukocyte function-associated molecule 1 alpha chain; antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide

Plasma membrane

Diseases associated with ITGAL include Immune-Complex Glomerulonephritis and Chronic Venous Insufficiency.

Its related pathways are Integrin Pathway and Degradation of the extracellular matrix.

Integrin Itgal / itgb2 is the receptor of ICAM1, icam2, icam3 and icam4. Integrin Itgal / itgb2 is the receptor of F11R. Integin Itgal / itgb2 is the receptor of secretory ubiquitin like protein ISG15; this interaction is mediated by Itgal. It is involved in a variety of immune phenomena, including leukocyte endothelial cell interaction, cytotoxic T cell mediated killing, and antibody dependent killing of granulocytes and monocytes. Contribute to natural killer cytotoxicity. It is involved in the adhesion and transport of leukocytes including T cells and neutrophils. The need to produce common lymphoid progenitor cells in the bone marrow indicates their role in lymphogenesis (through similarity). Integrin Itgal / itgb2 is associated with icam3 and contributes to macrophage apoptosis and neutrophil phagocytosis.

In resting T-cells, up to 40% of surface ITGAL is constitutively phosphorylated. Phosphorylation causes conformational changes needed for ligand binding and is necessary for activation by some physiological agents.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

BioBet-1134ZP

Mouse

Human

Cytolin is a mouse monoclonal antibody originally developed to identify a specific type of immune cell called a cytotoxic T cell, or CTL. Subsequent work showed that the antigen to which Cytolin bound was the cellular antigen CD11a, which along with CD18 makes up the cellular adhesion molecule LFA-1. In the 1990s a number of researchers reported that LFA-1 appeared to be critical for HIV infection.

HIV Infection

HIV Infection