Non-Fucosylated Anti-Human Claudin 1 (6F6C3) Therapeutic Antibody (CAT#: BioBet-713ZP) Datasheet

CLDN1

claudin 1

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.

CLDN1; claudin 1; CLD1; SEMP1; ILVASC; claudin-1; senescence-associated epithelial membrane protein 1

Plasma membrane

Diseases associated with CLDN1 include Ichthyosis, Leukocyte Vacuoles, Alopecia, And Sclerosing Cholangitis and Sclerosing Cholangitis.

Its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling and Pathogenic Escherichia coli infection.

Claudins are the main components of tight junction complexes that regulate epithelial permeability. Some claudin family members play an important role in the formation of impermeable barriers, while others mediate the permeability of ions and small molecules. Usually, several claudin family members express and interact together, which determines the overall permeability. CLDN1 is necessary to prevent the spread of small molecules through the adjacent cells of the epidermis, and it is also necessary for the skin's normal barrier function. Since CLDN1 itself seems to be essential for the formation of a water barrier in the tight junctions of keratinocytes, CLDN1 may indirectly affect the expression levels of other proteins to maintain normal water homeostasis and prevent excessive skin moisture loss. (Microbial infection) As a receptor for hepatitis C virus (HCV) in liver cells. The association with the CD81 and CLDN1-CD81 receptor complex is essential for the entry of HCV into host cells. As a recipient of dengue virus.

1.UModification sites at neXtProt 2.Modification sites at PhosphoSitePlus

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

6F6C3

Humanized

Human

Monoclonal antibody against the HCV entry factor CLDN1 might be used to prevent HCV infection, such as after liver transplantation, and might also restrain virus spread in chronically infected patients.

Hepatitis C viral infection

Hepatitis C viral infection