Full Name
angiopoietin-like 3
Background
This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metablism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2.
Alternative Names
ANGPTL3; angiopoietin-like 3; ANL3; ANG-5; FHBL2; ANGPT
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with ANGPTL3 include Hypobetalipoproteinemia, Familial, 2 and Hypobetalipoproteinemia, Familial, 1.
Related Pathways
Its related pathways are Lipoprotein metabolism and Metabolism.
Function
As a heparin, it participates in the regulation of lipid and glucose metabolism. It is believed to play a role in the transport of energy substrates (similarity) in the reaction of food intake to storage or oxidized tissues. It has a promoting effect on plasma triglycerides (TG), which is achieved by inhibiting the activity of LPL and inhibiting the clearance of plasma triglycerides. Inhibition of LPL activity seems to be an indirect mechanism involving the proprotein convertase PCSK6 and furan to LPL, leading to the cleavage and dissociation of LPL from the cell surface; this function does not require ANGPTL3 proteolysis, but appears to be mediated by the n-terminal domain , Not inhibited by GPIHBP1. It can inhibit endothelial lipase, leading to increased levels of high-density lipoprotein cholesterol and phospholipids in plasma. It can be combined with fat cells to activate lipolysis and release free fatty acids and glycerol. Especially inhibit LPL in oxidized tissues, oxidized tissues require very low-density lipoprotein (VLDL)-TG to be stored by white adipose tissue (WAT) to deal with food; its function may be related to the expression of circulating and hepatogenic ANGPTL8 and ANGPTL4 in WAT ( Similarity) related. Helps reduce plasma low-density lipoprotein (LDL)-cholesterol levels, and its mechanism is independent of the typical pathways involving APOE and LDLR. May stimulate LPL activity in the hypothalamus (similar). 发送反馈 历史记录
Post-translational modifications
O-glycosylated at Thr-226 by GALNT2; blocks processing and activation by proprotein convertases. In part proteolytically cleaved by proprotein convertases; proposed to be involved in activation.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Clone
BioBet-562ZP
Description
This is a fully human antibody specifically binds and inhibits or interferes with at least one activity of human angiopoietin-like protein 3 (hANGPTL3). The human anti-hANGPTL3 antibody are useful in treating diseases or disorders associated with ANGPTL3, such as hyperlipidemia, hyperlipoproteinemia and dyslipidemia, including hypertriglyceridemia, hypercholesterolemia, chylomicronemia, and so forth.
Indication
Cardiovascular Diseases
