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Non-Fucosylated Anti-Human AChR (P90-131) Therapeutic Antibody (CAT#: BioBet-501ZP) Datasheet

Target
AChR
Isotype
IgG
Description
ADCC-Enhanced anti-AChR (P90-131) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.
Indication
Rhabdomyosarcoma
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced AChR antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
AChR
Full Name
acetylcholine receptor
Background
An acetylcholine receptor (abbreviated AChR) is an integral membrane protein that responds to the binding of acetylcholine, a neurotransmitter.
Alternative Names
AChR; acetylcholine receptor
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with CHRNE include Myasthenic Syndrome, Congenital, 4A, Slow-Channel and Myasthenic Syndrome, Congenital, 4B, Fast-Channel.
Related Pathways
Its related pathways are Succinylcholine Pathway, Pharmacokinetics/Pharmacodynamics and Transmission across Chemical Synapses.
Function
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Field of research
Neuroscience antibody
Post-translational modifications
1.Glycosylation at Asn86 and Asn161 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
P90-131
Host
Human
Species Reactivity
Human
Description
The human monoclonal antibody against the gamma subunit of the acetylcholine receptor (AChR) is used in the treatment of rhabdomyosarcoma.
Indication
Rhabdomyosarcoma

Rhabdomyosarcoma

Related Products

Non-Fucosylated Anti-Human AChR (P90-65) Therapeutic Antibody (CAT#: BioBet-502ZP)

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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