Non-Fucosylated Anti-Human ACE (4B10.17) Therapeutic Antibody (CAT#: BioBet-500ZP) Datasheet

ACE

angiotensin I converting enzyme

This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active.

ACE; angiotensin I converting enzyme; DCP; ICH; ACE1; DCP1; CD143; MVCD

Plasma membrane, Extracellular region or secreted

Diseases associated with ACE include Microvascular Complications Of Diabetes 3 and Renal Tubular Dysgenesis.

Its related pathways are Transcription_CREM signaling in testis and Peptide hormone metabolism.

Angiotensin I is converted to angiotensin II by the release of terminal His-Leu, which leads to an increase in the vasoconstrictive activity of angiotensin. It also inactivates bradykinin, a powerful vasodilator. It also has glycosidase activity and can release GPI-anchored protein from the membrane by cleaving the mannose bond of the GPI part.

Cell Biology and Cellular Response antibody

Phosphorylated by CK2 on Ser-1299; which allows membrane retention.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

4B10.17

Rat

Human

The antibody demonstrated highly efficient and selective lung accumulation and thus has the potential for targeting drugs/genes to the pulmonary vasculature in different mouse models of human lung diseases, including numerous knockout models.

Lung Cancer

Lung Cancer