Non-fucosylated Anti-Human CA 125 (Abagovomab) Therapeutic Antibody (CAT#: BioBet-384ZP) Datasheet

MUC16

Mucin 16, Cell Surface Associated

This gene encodes a protein that is a member of the mucin family. Mucins are high molecular weight, O-glycosylated proteins that play an important role in forming a protective mucous barrier, and are found on the apical surfaces of the epithelia. The encoded protein is a membrane-tethered mucin that contains an extracellular domain at its amino terminus, a large tandem repeat domain, and a transmembrane domain with a short cytoplasmic domain. The amino terminus is highly glycosylated, while the repeat region contains 156 amino acid repeats unit that are rich in serines, threonines, and prolines. Interspersed within the repeats are Sea urchin sperm protein Enterokinase and Agrin (SEA) modules, leucine-rich repeats and ankyrin (ANK) repeats. These regions together form the ectodomain, and there is a potential cleavage site found near an SEA module close to the transmembrane domain. This protein is thought to play a role in forming a barrier, protecting epithelial cells from pathogens. Products of this gene have been used as a marker for different cancers, with higher expression levels associated with poorer outcomes. [provided by RefSeq, May 2017]

Abagovomab;792921-10-9;OC125;ACA125;clone 3D5;MUC16;mucin 16, cell surface associated;mucin-16;CA125;FLJ14303;CA-125;MUC-16;CA125 ovarian cancer antigen;ovarian carcinoma antigen CA125;ovarian cancer-related tumor marker CA125;

Extracellular region or secreted, Plasma membrane

Diseases associated with MUC16 include Ovarian Cyst and Clear Cell Adenocarcinoma.

Its related pathways are Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) and Metabolism of proteins.

Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.

Cancer antibody; Controls and Markers antibody; Signaling Transduction antibody

Heavily O-glycosylated; expresses both type 1 and type 2 core glycans. Heavily N-glycosylated; expresses primarily high mannose and complex bisecting type N-linked glycans. May be phosphorylated. Phosphorylation of the intracellular C-terminal domain may induce proteolytic cleavage and the liberation of the extracellular domain into the extracellular space. May contain numerous disulfide bridges. Association of several molecules of the secreted form may occur through interchain disulfide bridges providing an extraordinarily large gel-like matrix in the extracellular space or in the lumen of secretory ducts.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG1, κ

Abagovomab

Mouse

Human

ADCC-enhanced Abagovomab is a non-fucosylated anti-CA 125 therapeutic biobetter antibody.

Ovarian cancers

Ovarian cancers